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Inclusion at the country level required complete information on sampling weights and key covariates.
Samples were given unique identifiers and information on sampling location and type of outlet, submitter's details, manufacturing information (manufacturer, manufacturing and expiry dates, batch numbers), and the chemical and packaging analysis results were recorded.
Bayesian clustering without prior information on sampling location suggested that the most likely number of populations in our sample was three (K = 3 using Structure and Evanno's delta K method [ 45]).
In order to compare the results obtained from our methods with that from [ 17], we first attempted to collect all the original information on sampling distributions from each of the clinical trials papers used in [ 17].
To qualify for inclusion, case studies had to a) rely on at least one source of empirical information; b) report information on sampling, data collection, and/or analysis; and c) provide some analysis of the factors influencing success/failure of IS uptake.
We do not include information on sampling strategies because the goal of the monograph is to inform the National Children's Study.
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We also thank those who provided access to sampling sites (Bruno Le Vessier) and information on sampled fruits (Pierre-Michel Forget).
Geographic information on sampled individuals is provided in Additional file 5. Tetraploid confirmation was conducted on a Partec PAII flow cytometer.
Nine further population-based studies presented additional informative information on samples of children already represented [76-84].
Information on sample size, study design, Hardy Weinberg equilibrium, method of genotype determination, plasma folate and homocysteine were abstracted by two reviewers using a standardized protocol.
Information on sample size, study design, Hardy Weinberg equilibrium, and method of genotype determination was abstracted by two reviewers using a standardized protocol.
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