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These analyses were then repeated using information on changes over follow-up (a time-updated analysis) to assess whether the results were robust to any such changes.
A limitation is that we do not have information on changes in smoking habits during follow-up.
We lack information on changes regarding the covariates during the follow-up.
First, we defined lifetime NSAID use based on the information collected at baseline and did not include information on changes in NSAID use during the study follow-up.
Second, since we did not have information on changes in any of the baseline variables during follow-up, we could not assess how any changes might have influenced the results.
First, we did not have information on changes in disease severity that may have occurred during follow-up.
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As shown in Table 2, adding information on change in HbA1c over time did not improve predictive ability over information on HbA1c at follow-up (aROC 0.78 [95% CI 0.76, 0.80] for both Models 4 and 5; p = 0.99).
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