Exact(6)
For improved reliability assessment, this version combines a new score derived from the experimental information of the interactions with the original score based on the features of the interacting proteins.
The direction information of the interactions was easily incorporated by confining the flow directions.
Functional enviromics maps are intended to compile large-scale quantitative information of the interactions between environmental factors and cellular functions.
The VHPIN does not show any information of the interactions happening in successive next steps (step 3, 4 and so on).
Our analysis, along with our recent application of this algorithm in other complex diseases (schizophrenia [ 5, 57], hepatocellular carcinoma [ 37], and epilepsy [ 6]), has demonstrated this strategy is practical and could provide valuable information of the interactions among DEPgenes.
Another issue is that we only have the information of the interactions, but do not know which drug target pair has no interaction, i.e., no negative samples in the training process.
Similar(54)
The semantic relations provided information on the interactions of these differentially expressed genes with other biomedical concepts.
A further analysis of the derived dynamic model provides information on the interaction of the dominant structures in the flow.
Here, the authors designed model peptides corresponding to domain IV segment 6 (DIVS6) of rat skeletal muscle Nav1.4 and analyzed the complex of the model peptides and VTD by solution NMR analysis to obtain structural information of the interaction.
This extended functional analysis provides the researcher not only with a quick an easy interpretation of the combined data but also with the additional information of the interaction term in the model.
High resolution crystal structures provide the most detailed information of the interaction interface but cannot always be obtained.
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