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It has however been improved since 2009 with data from the Ministry of Education, and so we use the latter information, imputing it backwards (see De la Roca and Puga 2016, footnote 7).
Missing information was imputed using multivariate imputation by chained equation method [ 34].
In order to avoid this loss of information, we impute the information on union membership and take advantage of the panel dimension of our data.
We defined two populations for analysis: protocols where missing information was imputed and protocols that reported all core components and any additional information such as adjustments for multiple testing required to accurately recalculate the sample size (complete reporting).
For candidate SNPs not directly genotyped in the Genentech samples, genotype information was imputed using IMPUTE version 2 (48) with combined reference data of CEU and TSI population from the 1000 Genomes Project (June 2010 release) and HapMap3 Project.
Given the small number of respondents for whom licensing-related information was imputed (n = 23), imputed values had minimal impact on the overall results.
4 5 6 Missing information was imputed in four ways.
Missing information was imputed from similar patients treatment at the same hospital.
Each missing information was imputed twenty times, given its binary nature and the large amount of missing data.
If information is imputed, the reader should be told how this was done and for which items.
Consequently, users of models employing the UKPDS 82 risk equations will need to ensure missing risk factor information is imputed with care.
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