Exact(6)
Second, even when such ranking of pathway activation can be determined, this information does not always improve the overall understanding of the underlying biology since only qualitative information about pathway modulation, i.e., whether a pathway is up- or down-regulated, is transferable across experiments.
In addition, our analysis may clarify potentially important directional information about pathway alterations.
For cases in which our modules overlap with the clusters identified with HC (Schuldiner et al., 2005), our modules tend to contain additional information about pathway cross talk.
In contrast, isotopic labeling analysis provides information about pathway fluxes but most commonly only for a limited number of metabolites that are measured with targeted methodologies.
KEGG pathway map images, besides containing information about pathway nodes and their interactions, are also decorated with various graphical notations for visualization of spatial distribution of pathway components (i.e. cells, cell and nuclear membranes, organelles, and structural proteins).
Both the KEGG and Reactome maps also lack significant additional information about pathway entities (e.g., PubMed IDs, supportive references) and neither is readily amenable to computational analysis approaches unless their pathways are converted to standard file formats that can be imported to analytic tools such as Cytoscape.
Similar(54)
Each F-D curve exhibits a specific pattern, which contains information about unfolding pathways and stable intermediates, and their probabilities of occurrence when unfolding the protein.
In spite of environmental factors, the discovery of nuclear modifier genes provides additional information about pathways in which the primary mutation functions, as well as new entry points for understanding the pathological effects of certain disease gene.
Further research into what causes this variability could provide important information about pathways of and the role of epigenetic alterations in cancer progression.
Several databases contain information about pathways and their associations to diseases.
We were able to demonstrate that integrating information about pathways can provide additional molecular insights, highlighting a few key genes and pathways.
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