While the informatic validation of the ranking procedure was encouraging, it was important to provide evidence that protein abundance changes could be correctly predicted.
While both TargetScanS and PicTar predict mammalian miRNA targets based on sequence complementarity, evolutionary conservation, and binding energy, they were reported to have high fidelity for target prediction from biological and informatic validation [ 11, 47].
What will validation validate?
CM Ronning performed informatic analysis and validation, drafted text sections, and edited and organized the manuscript for submission.
Both informatic and protein detection validation was used to verify the predictions of in vivo changes.
The rapid evolution of sequencing technology, informatics tools and RMs make validation and optimization a continuous process in which these results represent a particular moment in time.
This problem was minimized, thanks to regular quality control of the database by the health provider, continuous training of physicians, and specific validation of the informatics system.
Terminal masters and doctoral programs, as well as post-doctoral fellowships, usually focusing on the discovery and validation of novel informatics theories and methods.
For other researchers, additional omic validation and some informatic evidence would likely be required to make this finding worthy of laboratory investigations.
In this method the points are assigned such that roughly equal weight is given to the three categories of validation evidence (omic, informatic, and experimental).
