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With appropriate informatics support, shared protocols, and facilitative cultural elements, common diseases can be studied on a larger scale and clinical trials in rare diseases will be able to accrue adequate sample sizes.
In-house access to patent Markush data could provide improved informatics support to the drug discovery process, both to enable patentability criteria to be added to computer-assisted drug design, and to expand the techniques available for data-mining in the patent literature.
We would like to thank Amanda Miotto and Othmar Korn for informatics support.
We thank Stephen Johnson and Robert Lundsten for informatics support on the New York Cancer Project samples.
Realtime PCR data expressed as Ct values from array A and B were combined using R script (provided by GeneSpring Informatics Support Team) and processed using GeneSpringGX 11.0.2 software (Agilent Technologies, Santa Clara).
LC provided informatics support.
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Molecular graphic images were produced using the UCSF Chimera package (http://www.cgl.ucsf.edu/chimera) from the Resource for Biocomputing, Visualization, and Informatics (supported by NIH P41 RR-01081).
The informatics supported architecture allows the CDEs that are used to annotate the biospecimens to be semantically and syntactically interoperable by describing them in the form of metadata or data descriptors.
AP provides informatic support for the project.
Timothée Cezard, Sujai Kumar and Graham Thomas gave essential analytic and informatic support.
The Authors thank Jane Bryce, Gianfranco De Feo and Rosa Fiore for assistance in data collection and quality control; Federika Crudele, Giuliana Canzanella, Fiorella Romano, Manuela Florio, Giovanni de Matteis, Amalia Rocco and Gaetano Bonfanti for data management; Alfonso Savio for informatic support and the Campania section of the Lega Italiana per la Lotta contro i Tumori.
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