The concept of tissue banking and the informatics infrastructure coupled with it has emerged as a successful strategy to support clinical and translational research.
Thus, data derived from multiple proteomics platforms and transcript data coupled with informatics analysis provides a deeper insight into the functional consequences of androgen action in prostate cancer.
By contrast, plasma markers were reported to show promise in ALS (Turner) and in MS. Peter Schultz-KnaProtagentAGen AGermanyany) described the use of a multiplex antibody array coupled with informatics to identify a panel of plasma markers that discriminated patients with MS from healthy controls with a higher level of precision than a single marker.
Using this new ability, coupled with bio-informatic tools, it is now possible to define the immunogenic repertoire of any tumor to a high degree of granularity within a practical time frame and an acceptable cost.
Coupled with a multitude of bio-informatic methodologies publicly available on the Internet and made available by consortia of laboratories, investigators can now mine these databases to explore the presence of unique gene sets, the distribution patterns of gene expression, and the possible existence of unique structural features in predicted gene products.
The variety of questions, coupled with challenges in methodology ranging from statistics to informatics, requires different viewpoints.
As a result, clustering has been coupled with many real problems, including bioinformatics [21], medical and health informatics [22], psychological study [23], marketing research [24], customer relationship [25], and recommender systems [26].
Additionally, there are several digital imaging applications which are emerging in pathology, such as image analysis using algorithms, coupled with computer-assisted diagnosis and 3D imaging, which have enhanced the field of biomedical informatics [ 12].
The recent large-scale informatics analysis of 62 bacterial T4SSs revealed a highly conserved core set of T4SS components (VirB6, VirB8-VirB11, VirD4) coupled with a depauperate complex of the remaining Vir components, of which the latter were suggested to have been acquired in various independent events [29].
coupled with a mid-80s fastball.
