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Provision of query systems which are intuitive for non-experts has been recognized as an important informatics challenge.
Hence, the informatics challenge in healthcare local improvement initiatives consists of providing a mechanism for rapid modelling of the local domain by non-informatics experts, including performance metric definitions, and grounded in established improvement techniques.
However, growth of both phenotypic and genetic knowledge of human diseases imposes a great informatics challenge.
At this time, the huge amount of data generated by next-generation sequencing creates an informatics challenge.
Furthermore, NGS platforms usually produce very short reads (e.g. 35 100 bp); accurate de novo assembly of such short reads poses a significant informatics challenge.
Therefore, an informatics challenge is how to map the neuronal patterns onto a 'standard' brain in an accurate, reliable and automatic way.
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Here, we suggest that getting our own houses in order by first employing interoperable solutions that support and facilitate collaboration amongst the complementary disciplines within our own institutions places the informatics community in a better position to address global informatics challenges.
For RNA-seq, several informatics challenges should be considered.
Acetaminophen data sets were collected from three different independent studies (NCT008, NTP and NCT informatics challenges).
The marriage of toxicology and genomics has created not only opportunities but also novel informatics challenges.
However, users of the device are faced with a number of informatics challenges.
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