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This would help inform samples sizes for multicentre studies, particularly for use in prevaccine and postvaccine studies, as well as to aid in understanding the effects of demographic factors and deprivation on carriage.
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Some populations targeted in survey research can be hard to reach, either because of lack of contact information, or non-existent databases to inform sampling.
If available, additional information concerning the primary sources, routes of exposure and temporal variability will help inform sampling strategies, interpret the health implications of the data and provide the basic information for advice to limit exposure, if necessary.
The results of these analyses could be presented in the studies' technical documentations and may inform sample adjudication.
These data will inform sampling for future trials.
Data from this study was predicted to inform sample sizes required for future large carriage studies.
This was an exploratory study to inform sample size for future studies.
The results of this study may help inform sample size estimates for such a study.
In a second step, we investigated how the mathematical model can inform sample size calculations in general.
These methods have the potential to inform sample size calculations where there are concerns of patient acceptability.
This study showed how a mathematical model can be used to inform sample size considerations for RCTs.
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