In this case, accumulation of nuclear DNA damage induced by irradiation reaching a certain threshold is able to trigger adaptive cellular response by activating a nuclear-to-mitochondrial protein influx including p53, cyclin B1 and Cdk1.
Ras is localized to the inner face of the plasma membrane and functions as a molecular switch that transmits receptor signals, but it can also be regulated by pathways dependent on Ca2+ influx, including at least one calmodulin-dependent pathway.
Recently, in our laboratory, we used mice spermatozoa to evaluate the interrelationship of proteins related to Ca2+ influx, including UQCRC2 [ 39], arginine vasopressin [ 5], and VDACs [ 4], and evaluate their effects on capacitation and the acrosome reaction.
The enhanced cellular influx, including that of CD4+ and CD8+ T cells, observed in Mtb infected IL-10−/− mice as compared with WT control mice was unaffected by neutralization of IL-17 (Fig. 5A C).
Both Aβ peptides and other proteolytic fragments derived from APP can interact with membrane channels that regulate Ca2+ influx, including NMDA channels, AMPA channels and voltage-gated Ca2+ channels (LaFerla, 2002).
The accumulation of A2M within the AS plaque did not correlate with the type of the AS lesions [ 71] suggesting that plasma protein influx including A2M may play a role in the initiation of AS plaques but not for plaque rupture.
Inhibition of IP3 generation and Ca2+ flux by SLPI may represent a novel anti-inflammatory mechanism, thus strengthening the attractiveness of SLPI as a potential therapeutic molecule in inflammatory airway disease associated with excessive neutrophil influx including CF, non-CF bronchiectasis, and COPD.
They form pores in membranes of bacteria after oligomerization and these pores may cause transmembrane ion influxes, including Na + and K+, which result in membrane disruption and cell death.
Large influxes include 15,000 birds on the Isle of May in October 1982, and nearly 21,000 birds through a single site in Latvia during September and October 1983.
For instance, TRPM7 has been implicated in various cellular functions, many of which are dependent on Ca2+-influx, including cell proliferation, anoxic cell death, exocytosis, mechanotransduction, actomyosin contractility and cell adhesion [3], [8] [15].
