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We selected our patients using a hospital influenza screening database of adult patients (age> = 16 years) seen during the epidemic containment period, which lasted from 27 Apr 2009 till end of June 2009.
It is likely that transmission of influenza and both the morbidity and mortality of influenza could be reduced if inexpensive but reliable influenza screening assays were more available to the general public or local medical treatment facilities.
TTSH is a 1500-bed tertiary hospital in Singapore and was designated the primary national center for adult influenza screening, treatment and isolation of H1N1(2009) cases.
Influenza screening in Singapore found that only 12% of cases of pandemic (H1N1) 2009 infection with onset within 10 days of arrival were detected by ITIS on entry [11].
Our study was conducted in a single geographical area and the inclusion of only patients with laboratory confirmed influenza and these factors may limit the generalizability of our data to areas with different approaches to influenza screening.
The findings led the authors to recommend routine influenza screening in intubated patients during influenza season.
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We have included this observation, but because the sample size for Ebola importations is so small, we used data from previous influenza A/H1N1 screening initiatives for comparison with model-predicted outcomes.
We chose to model 50 infected travellers in this study precisely because this number is consistent with the number of infected air travellers during past influenza A/H1N1 screening initiatives.
Even in the absence of chronic illness, older adults need to access medical care for acute conditions as they arise, as well as for extensive preventive care services recommended by evidence-based guidelines (e.g., annual influenza vaccination; screening for hypertension, hypercholesterolemia, and many cancers) [ 2, 3].
Compared with assays exploiting the principle of cytopathic effects (CPE) protection, the approach established here is rapid and simple for anti-influenza inhibitor screening.
Sensitivity of our influenza-screening method would have been sufficient to detect recently reported virus concentrations in plasma of infected persons (15 ).
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