Pandemic influenza represents an even greater threat, with numerous potentially pandemic viruses circulating in nature.
Influenza represents a particularly problematic therapeutic challenge since high viral mutation rates have often confounded many conventional antivirals.
He has repeatedly challenged the idea that influenza represents a major public health threat, despite the fact that it infects tens of millions of people (3-5 million cases of severe illness) and causes 250-500,000 devery everyearar, including 20,000 in the U.S. alone.
Pandemic influenza represents a major threat to global public health, with the potential for sudden emergence and explosive transmission of virus strains to which humans have little or no serologic immunity.
Paediatric influenza represents a substantial burden to public health.
In conclusion, pandemic influenza represents an unpredictable and critical public health emergency.
In total, 793 000 working days were lost due to influenza, representing a total productivity loss of $231 million.
In the elderly, influenza represented a large burden on the assessed healthcare systems, with yearly excess hospitalization rates of ~30/100 000.
Recurrent seasonal influenza represents a significant part of this market, with 5 to 10% of the world population being infected each year by the influenza virus.
