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An influential assumption is that novel stimuli, which have uncertain consequences, attract more attention and enhanced rates of learning about their associated properties than familiar stimuli [103,104].
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identify influential assumptions and to assess the face validity and internal consistency of the model.
Despite a lack of transparency in some key elements, the most influential assumptions were identified as relating to vaccine effectiveness, cervical screening, and model design.
Among the challenges with disease-specific modeling include the need to identify influential assumptions and to assess the face validity and internal consistency of the model.
The most influential assumptions in untreated women included chronic HIV-associated mortality following an opportunistic infection, and in treated women, the 'clinical effectiveness' of HAART and the ability of HAART to prevent HIV complications independent of virologic suppression.
This process required that data be extracted from the Women's Interagency HIV Study (WIHS) and adapted to a format required by the model.[31] [34] We used this effort to assess the internal consistency of the model, identify influential assumptions on model outcomes, and assess the external consistency of the model with independent published analyses.
Other influential assumptions on the cost-effectiveness ratio include the values used for vaccine efficacy and the annual discount rate.
Nevertheless, passivity remains an influential background assumption in large parts of neuroscience where reactions to stimuli are held central rather than endogenous activity (Raichle 2010) and thus can be considered typical.
Adjustment of influential treatment assumptions (e.g., 'clinical effectiveness', the ART effect and the CD4 gain on treatment) individually across all lines of HAART did not produce a good fit to either 12- or 24-month survival.
This illustrates how prevalent and influential the assumptions are about the expected norms of behavior and interaction at a scientific conference.
Detailed information about how major joint arthroplasty in routine practice affects patients' lives can be used to advise patients and clinicians and can invalidate influential, but inaccurate, assumptions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com