The novel data set was used to examine how auxin influences tissue-specific transcriptional regulation of cell-identity markers.
The main restriction of the sheep model is the much larger translatory capacity compared with patients, which adversely influences tissue healing.
"We started this work more than a decade ago, with a kind-of crazy hypothesis that there might be something in the blood that influences tissue repair with age," says Amy Wagers, a researcher at the Harvard Stem Cell Institute, who is a coauthor on two of the three new works.
Thus collateral blood flow partially sustains myocardial oxygenation during coronary artery occlusion and influences tissue reoxygenation early during reperfusion.
These modifications determine the pattern of collagen cross-linking which in turn influences tissue organization, mineralization, and ultimately mechanical bone strength [56], and in the case of osseointegration, the integrity of the bone-implant interface [37].
A sustained release of PDGF not only influences tissue neogenesis and neovascularization, but also impacts the PDGF-induced gene profile of chemokine family members, actin, and interleukins.
We also investigated whether impaired NE reuptake influences tissue levels of catecholamines and metabolites.
The effects of blood transfusion in patients with sepsis, and in particular how it influences tissue microcirculation, are poorly understood.
Although PTEN influences tissue homeostasis through Cdc42 signalling (Langlois et al, 2010), the role of Cdc42 activity in PTEN-dependent cell death remains unclear.
SpO2 measures the percentage of hem groups in hemoglobin which are bound to oxygen (Moore et al., 1998), and influences tissue oxygen delivery.
