Exact(31)
This difference, together with interactions conveyed via substituents that are specific to certain ketolide and macrolide sub-classes, influences the binding to the large ribosomal subunit.
In vitro biological testing of the designed inhibitors shows that elimination of R, S stereoisomerism and restriction of conformational freedom influences the binding of inhibitors in a favorable fashion.
Furthermore, EndoS hydrolysis of the IgG glycan influences the binding of IgG to immobilized soluble FcγR and to an erythroleukemic cell line, K562, expressing FcγRIIa.
Additionally, we found that EndoS hydrolysis of the IgG glycan dramatically influences the binding of IgG to soluble, immobilized FcγRIIa and FcγRIIb as well as to FcγR-expressing cells.
We have previously shown that BRCA1 can bind to eight novel promoters containing the TTC(G/T GTTG consensus site [42] and wondered whether methylation of BRCA1 influences the binding of BRCA1 to these promoters.
To explore the nature of the cooperative activity of PUF60 and U2AF65/35, we tested whether one protein influences the binding of the other to a 3' splice site.
Similar(29)
IκBα and Notch both undergo partial folding upon binding perhaps influencing the binding free energy.
The alanine substitution of K203 that directly interacts with RNA cap was expected to severely influence the binding and activity of the cap1 MTase.
Although the azide moiety is small, in some cases its introduction strongly influenced the binding affinity.
The non-active site mutations influence the binding of the inhibitor indirectly and their resistance mechanism is not well understood.
Since L418A mutation site is structurally far from the active site, it cannot influence the binding of the substrate directly.
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