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Cox regression analysis was employed to determine whether date of birth, parental identity, genotype or experimental cohort (experiment 1 [12] or current experiment) influenced lifespan significantly in female mice.
The Siler parameters that primarily define the early childhood component of mortality (α1 and β1) influenced lifespan variability substantially when early-life mortality was still high at the turn of the twentieth century, but this influence waned as the absolute value of the parameters shifted to reflect declining levels of mortality in infancy and the childhood years.
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Although the effects of playing position on lifespan longevity may be more pronounced in contact sports such as football, we cannot overlook the differences and nuances in health-related behaviors between and within sports that may influence lifespan longevities.
Although there has been some evidence that former intercollegiate student athletes fail to maintain higher exercise levels later in life [75], our understanding of the impact of different longitudinal lifestyle factors influencing lifespan longevity remains incomplete.
Caloric restriction (CR) is one of the most extensively studied feeding regimes shown to influence lifespan.
We aim to understand the mechanistic basis through which maternal diet influences lifespan in mice.
Over time, these factors are likely to exert selective pressures that could influence lifespan.
Although presumably not influencing lifespan, it is possible that the elevated oxidative stress leads to the phenotypic defects observed in PaCox17::ble.
We also checked association of lifespan with several haplotypes composed of combinations of significant markers from the regulatory region that were most likely to influence lifespan through transcription alteration.
It will be important to test this possibility and determine whether or not CR induces feminizing gene expression changes in organisms that have a clear female lifespan advantage, such as humans, and whether such changes might influence lifespan.
The PTEN tumour suppressor encodes a phosphatase, and its daf-18 orthologue in Caenorhabditis elegans negatively regulates the insulin/IGF-1 DAF-2 receptor pathway that influences lifespan in worms and other species.
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