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Within this variability, the sequencing lane significantly influenced error frequency for individual samples.
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Similarly, the number of increment trials also influences error performance and decoding complexity.
This in turn influences error processing measured by the Ne.
This approach did not prevent us from extracting the common trends influencing error rate and distribution.
This explanation is, however, insufficient in itself to account for the observed pattern, and other variables clearly influence error rate.
Fourth, the culture of individual ICUs, the number of ICUs participating in error reporting, and the technologies employed can significantly influence error reporting.
This overall variability of error distribution makes it difficult to draw any clear conclusions ruling out particular parameters that might potentially influence error rates or to identify a single mechanism accounting for the observed errors in the dataset.
There is growing evidence that sequence context (i.e., the nucleotide sequence surrounding a base and the base's position within the read) influences error rates in both Roche/454 and Illumina sequencing [ 8, 9].
Both the mean and variance of evidence can influence error rates and prolong decisions (de Gardelle and Summerfield 2011), suggesting that human observers can compute such summary statistics about visual stimuli (for a review, see Alvarez 2011).
Vincent and colleagues 14 adapted Reason's Swiss Cheese model to patient safety, and described management decisions and latent failures that can influence error and create conditions that produce safety violations.
These results suggest that, while the type of change introduced did not influence errors, a host of other common factors did have an impact.
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