Sentence examples for influence this pathway from inspiring English sources

A number of strategies to influence this pathway have been designed, one of which involves the putative advanced glycation end-product (AGE) crosslink breaker, alagebrium which has been shown in in vitro studies to cleave preformed AGE crosslinks.

This would be consistent with the overall implication of PKA regulatory proteins in Herceptin resistance discussed earlier and the known function of Darpp-32 as a PKA inhibitor [29], but the mechanism by which t-Darpp might influence this pathway is not known.

It has been proposed that Cdk1 may influence this pathway selection, but a mechanism has not been identified.

Either the duration of the experiment was insufficient to reveal possible differences or other genes that are unaccounted for at present influence this pathway.

Wnt growth factors have been shown to influence β-catenin activity, when normal controls have been lost through β-catenin mutation as occurs sometimes in colorectal cancer (Suzuki et al, 2004), but do not appear to influence this pathway in the presence of APC mutations (DeAlmeida et al, 2007), which are more common in genetic and sporadic disease.

While cultural factors such as light exposure, temperature, plant nutrition, and ontological development are known to influence this pathway, numerous factors were evaluated in the current study and were insufficient to facilitate a reproducible protoplast isolation protocol from American elm (data not shown).

We aimed to identify food intake patterns influencing this pathway and evaluate their association with incident diabetes.

There are some similarities with RAS-MAP disorders, and abnormalities of KAT6B may act in part by influencing this pathway.

However, it is presently unclear how TORC1 influences this pathway; TORC1 inhibition could indirectly influence retrograde response signaling via alterations in metabolite levels.

Since ligands and other agents influencing this pathway have revealed anticancer effects in a variety of human cancers [ 49, 50] efforts to target this signaling pathway should certainly be intensified given the broad range of tumors with deregulated PPAR signaling.

Therefore, the results obtained had no influence from this pathway.