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These properties can positively or negatively influence the vascular system.
Fourth, we did not collect data from a control cohort of elderly patients (a factor that can influence the vascular response); however, our control group was designed to provide a picture of the normal physiological response and, more importantly, our main findings are related to the differences between survivors and non-survivors.
Finally, bradykinin B2 receptor antagonist, [d-Arg0,Hyp3,Thi5,d-Tic7,Oic8]-bradykinin (HOE 140, 5×10−8 mol/l) significantly reduced the effect of angiotensin-(1 7), while bradykinin B1 receptor antagonist, des-Arg9, [Leu8]-bradykinin (6×10−9 mol/l) did not influence the vascular response to the heptapeptide.
Particularly, the risk alleles may influence the vascular tone likely through an abnormal elevation in vascular smooth muscle tone, leading to smooth muscle dysfunction.
The genes identified, PRKG1, SLC24A3 and SLC8A1, influence the vascular tone likely through an increase in the concentration of cytoplasmic calcium (Ca2+), and may represent a significant key node for systemic BP regulation.
It has been shown that circulating pro-inflammatory cytokines influence the vascular expression of AT1R.
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The RCS-induced formation of AGEs could thus be influencing the vascular complications observed in diabetes patients.
In addition, to investigate whether the benzodiazepine-receptor antagonist, flumazenil, or μ-opioid-receptor antagonist, naloxone, influenced the vascular effects of JM-1232.
Patients and controls were matched for age, as ageing influences the vascular substrate and the development and progression of atherosclerosis.
In our model system, we have shown that the molecular nature of KRAS mutations clearly influences the vascular strategy devised by the tumour cell.
For example, Ledoux and colleagues [ 8] used dopamine in addition to NE, and the use of a second vasoactive agent may have influenced the vascular reactivity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com