Sentence examples for influence the normalization from inspiring English sources
Note that, while the power parameter in the weighted mean normalization method provides a convenient way of adjusting how much one wishes to let the less stable microRNAs influence the normalization of other microRNAs, its optimization currently requires enumeration of different values and using the one with the best overall stability.
Applying the same normalization strategy, both datasets were jointly and independently normalized to study the influence of the normalization to the final results.
These observations suggest that the influence of the normalization is strongly problem dependent.
This result highlights the influence of the normalization step on the differential expression analysis.
During our analysis we recognized the strong influence of the normalization scheme on the performance of the distance measures.
In addition, to exclude the possibility that our results were influenced by the normalization method, we repeated all the analyses with a different method, i.e. the median normalization method in which each sample was centred based on the median value of all the 147 expressed miRNAs.
We first re-analyzed the Whitehead Institute dataset to determine the influence of normalization on the sensitivity and precision of peak identification using Splitter, since this was not discussed in [ 13].
As reported in the latter study, doping of the particles with Sm results in a slight increase in primary particle size, but it was concluded that this does not influence the results as normalization per surface area of the doped nanoparticles did not substantially affect the results with respect to antioxidant effects20.
6, 10, 12, 14 Future studies could focus on which factors influence the duration of normalization.
In conclusion, our results suggest that, depending on the RNA-seq data structure and the applied method, the influence of normalization differs.
In this paper we have shown that, depending on the data structure, the influence of normalization differs (see Figures 1 and 2(d)).
