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Cell attachment in turn can influence proliferation and differentiation.
Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment.
Moreover, we could demonstrate that the adhesion of ASCs on the WGA-SF does not negatively influence proliferation or differentiation potential into the osteogenic lineage.
The marriage of gene therapy and tissue engineering exploits the power of genetic cell engineering to provide the biochemical signals to influence proliferation or differentiation of cells.
Microvessel density and expression of VEGF and VEGF receptors were analyzed by immunohistochemistry. RESULTS: SLT-VEGF did not influence proliferation of pancreatic cancer cells; HUVECs (low-level VEGFR-2) reduced their proliferation rate and tube formation but not their viability.
It can also influence proliferation of T lymphocytes [2], [3].
Functionally, NGF moderately inhibits NK cell degranulation, but does not influence proliferation or cytokine production.
But CD137 ligand signaling has also been shown to influence proliferation and differentiation of hematopoietic progenitor cells [23] [25].
Cytokines crucially influence proliferation, survival and death of healthy and malignant B cell lymphoma cells as well as MM cells.
Other drugs beside rHuEPO are known to influence proliferation and differentiation of EPCs as well, e.g. statins [22] and angiotensin receptor blockers [23].
In the M. sexta olfactory system, rising ecdysteroids influence proliferation of glial cells associating with olfactory lobe neuropile, but not neurite outgrowth of olfactory lobe neurons [55], [56]; falling ecdysteroids stimulate expression of odorant binding proteins in the antenna [38].
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