Sentence examples for influence origin from inspiring English sources

The molecular mechanisms through which Rb might directly influence origin activity are unclear.

For example, complex chromatin structure (e.g., heterochromatin) and transcriptional domains, both of which are of limited or no influence to embryonic chromatin, may influence origin firing in somatic cells.

To this end, we first considered proteins known to influence origin activity.

Detailed analysis of ARS1 suggests that factors that position nucleosomes surrounding origins (including ORC itself) influence origin initiation efficiency [ 5, 27- 29].

Here we have investigated the effects of MEK5/ERK5 signalling on the DNA replication initiation machinery in prostate carcinogenesis to determine how this might influence origin licensing and cell cycle kinetics of this tumour type in vivo.

The misregulation of metabolic processes could cause too many regions to fire, which could subsequently lead to the depletion of nucleotide pools and replication factors such that replication forks cannot proceed with optimal speed 37. Therefore, cohesin may influence origin usage, firing fidelity, and timing in part through its effect on gene expression.

Although local chromatin structure and function influences origin activity, the exact mechanisms remain poorly understood.

These observations suggested that in the absence of external influences, origins are inherently early activated, and that later firing origins are delayed in their activation because of their particular surrounding sequences.

This latter behaviour has two origins: one in which the bulk of the bed where the coordination number is maximal and constant exerts increasing influence (volumetric origin), and one in which the packing density inherently decreases with the bed-to-particle diameter ratio (packing origin).

In the second section, the 5 chapters review how interactions between microbes and various natural biotic and abiotic factors can influence the origin and evolution of virulence in microbial pathogens.

The mtDNA content of blood cells is slightly lower in healthy individuals with the OriB variant than in those with wild type, suggesting that sequence variants might influence this origin's activity [ 40].