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"It is very, very clear that they are distinct entities and Michael will have no influence on coverage".
Spray volume has a greater influence on coverage than spray nozzle type and AIXR and TTI nozzles are less prone to coverage differences due to spray volume than the XR and TT nozzles.
Again, the randomization feature presented positive influence on coverage results, of around 8%% on average mutation coverage for the different logical criteria.
Although it was showed GC contents had significant influence on coverage depth in all three NGS platforms, the gaps, which are unable to be filled by SOLiD data, was most sensitive to GC contents.
The data indicated that the GC contents had significant influence on coverage depth, with the p-values (top 5% vs bottom 5%; Welch Two Sample t-test) being 2.2e-16 2.2e-166, 2.2e-16 for 454, GAIIx, and SOLiD, respectively.
With respect to prefractionation and biochemical preprocessing, the following parameters were assessed for their influence on coverage: (i) protein extraction buffers, (ii) enrichment and separation, and (iii) enzymatic proteolysis.
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On the contrary, considering the multiplicity of influences on coverage decision-making, the value of R 2 of the 'reasonableness' construct can be considered acceptable.
Additionally, we investigate the influence of coverage depth on prediction performance using a sample specifically enriched for the HLA region and simulated sequencing data.
To investigate the influence of coverage depth on prediction accuracy, artificial data were generated from all 1000 Genomes Project exome sequencing benchmark samples using randomized subsets of decreasing size drawn from the original reads to simulate different coverage depth conditions, until the number of remaining reads amounted to as little as ∼0.2× fold coverage on HLA-I loci.
Three national newspapers and the Associated Press may account for a large proportion of front-page coverage medical news and may exert considerable influence on media coverage of medical news in general.
We tested the influence of coverage and compliance rates on outcomes of campaigns with AL and DP by comparing asexual parasite prevalence one month after the end of campaign rounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com