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Finally, we ran the simulation through two more series with the influence factor set to 1.5 and 2 in order to develop sets of result with which to analyse the effects of social influence on cost effectiveness.
The CTC outcome parameter which was least well known – death rates among defaulters – had relatively little influence on cost effectiveness estimates.
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Because tumour growth rate had a clear influence on cost-effectiveness in the one-way sensitivity analysis, we investigated this factor further.
Furthermore, the results from a well-designed decision analysis study can guide further clinical and laboratory research based on the variables that have the greatest influence on cost-effectiveness.
Sensitivity analyses were performed to identify the influence on cost-effectiveness estimates of changes in key model parameters, including vaccine efficacy, vaccine coverage, sources of transmission to young infants, case fatality rates, rates of long-term sequelae and cost estimates.
This will result in very different treatment pathways with differences in resource use and costs and a consequent influence on cost-effectiveness results.
The influence on cost-effectiveness of changes in the values of production and consumption produced by mortality and sickness-related absenteeism was relatively small.
Although (as our analysis shows) low compliance with surveillance would have a relatively modest influence on cost-effectiveness, it would adversely impact on programme effectiveness.
Hence, additional research is needed to compare performance of each respective measure in the same populations (i.e. criterion validity, responsiveness and influence on cost-effectiveness ratios).
This dissimilarity in motivation might have had consequences for program execution during the study and underlines the importance of treating variation between HCCs as potential influence on cost-effectiveness.
Reporting 'net costs' is important because cost offsets have a major influence on cost-effectiveness, as well as the ongoing budget implications of funding interventions over the longer term.
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CEO of Professional Science Editing for Scientists @ prosciediting.com