Exact(14)
To clarify the structure function relationships and study the influence of the mutation on IFN-CSP stability, the three-dimensional structural models of the native IFN-CSP and the mutant Mu-IFN-CSP were constructed and the molecular dynamic simulations were conducted according to previous study (Bao et al. 2015).
To clarify the structure function relationships and investigate the influence of the mutation on the stability of the novel liver-targeting interferon, the three-dimensional structural models of the native IFN-CSP and the mutant Mu-IFN-CSP were constructed and the molecular dynamic simulations were conducted.
Regarding a potential influence of the mutation type on prognosis, our results, in contrast to the RASCAL study, show no differences with respect to mutation type.
The paternal influence of the mutation on the muscle phenotype indicates that a paternally expressed gene is likely to be causal.
There is also a strong influence of the mutation rate at which populations evolved towards the previous stationary state in their ability to adapt to new selective pressures.
The influence of the mutation rate on the degree of adaptation attained at the stationary state, and on the genotypic and phenotypic diversity of the population are questions that have been addressed previously with this model [9], [42].
Similar(46)
A significantly diminished activity exhibited by the mutants W377A, V209D and D382A (Fig. 6A) is in agreement with the marked influence of the mutations on the structural integrity of the protein as described in the above section.
The aim of the study was to identify the prevalence of HFE gene mutations in Czech patients with chronic liver diseases and the influence of the mutations on iron status.
Once a mutant version of the bait (A) is found, one can study the influence of this mutation on the phenotype.
In addition, it is possible that the fifth helix of PFN1 gets elongated under the influence of this mutation and the consequences of this are discussed below.
Furthermore, we evaluated the influence of these mutations on the structure of the mitochondrial network in human cells.
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