Sentence examples for influence of mutations from inspiring English sources

In addition, the methodology can also be used to infer the influence of mutations in the active site of the enzyme on its catalytic promiscuity.

This review presents two main in silico strategies to meet this challenge: a structure-based approach to study the influence of mutations on the drug-target interaction and a system-biology approach to identify resistance pathways for a given drug.

The influence of mutations of the residues Val209 and Trp377 emphasized their importance in maintaining the structural integrity of FadD13.

It is used for prediction of possible influence of mutations on CDR conformations, which usually results in loss of antibody binding affinity or even specificity.

Next, a putative confounding influence of mutations in the BRAF oncogene were analysed.

Moreover, medical scientists can get information about the influence of mutations on the drug metabolism and the in vivo activation.

The study further brings out the influence of mutation percentage on convergence.

Within this context, the influence of mutation age was analyzed under a simulation design, assuming presence or absence of selection on mutant QTL alleles.

Strong and significant correlations were observed, which indicates a dominant influence of mutation pressure.

We also quantified the influence of mutation rate on the ability to estimate N e.

The influence of mutation site on relative risk of breast or ovarian cancer has been a controversial issue.