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Mir-375 [ 22] and miR-9 [ 23] can influence insulin secretion, while mir-34a can increase hormone secretion in insulin-secreting cells when exposed to palmitate [ 24].
FFAs can act through GPR40 to influence insulin secretion by β-cells (Steneberg et al., 2005).
Several studies have indicated that G protein-coupled receptor (GPR) 40 (Ferdaoussi et al. 2012; Iglesias et al. 2012) and MAPK p38δ (Sumara et al. 2009) influence insulin secretion by regulating PKD activity.
Insomniacs in the high-insulin group are affected by other genetic changes, which may also influence insulin secretion.
Ephrin-A3 (EFNA3) was upregulated, which is of interest because this tyrosine kinase, has been found play a role in development and also influence insulin secretion [75].
To date, genetic variation in voltage-dependent Ca2+ channels (CACNA1E) and KATP (KCNJ11) channels have been shown to influence insulin secretion and type 2 diabetes risk [8], [9], and genome-wide association studies (GWAS) for type 2 diabetes in Caucasians have proven the importance of genes coding for proteins involved in insulin secretion [10] [14].
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Others have shown that serotonin influences insulin secretion (Isaac et al., 2013), and consequently glucose levels.
We also tested if experimental downregulation of PPARGC1A expression in human islets influenced insulin secretion.
This indicates that AKAP150 tethering of PP2B influences insulin secretion from β-cells.
Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.
Second, even among nondiabetic subjects, there are factors influencing insulin secretion and circulating insulin concentrations independent of insulin sensitivity.
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