These results suggest that amyloid does not have a significant influence on the modulation of activity in these attention-related regions, although it is important to note that these null findings are necessarily limited by the power afforded by our sample size and the sensitivity of our measures.
This key difference between our findings likely reflects the influence of environmental context in the modulation of the locomotor-activating effects of stimulant drugs [ 13] and suggests that SHR rats may be more sensitive than other strains to the attenuating effects of the home environment on stimulant-induced locomotor activity.
Insights concerning the ACE I/D and ACTN3 R577X polymorphisms' influence on the modulation of exercise-related phenotypes in adults are controversial.
Depending of the amino acid residues which are phosphorylated in the Hrs and Stam proteins, their influence on the modulation of signalling activity vary [49].
The influence of MEPE-ASARM peptides in the modulation of mineralization is due to a protein-protein interaction with PHEX, an X-linked phosphate-regulating endopeptidase homolog (also called the minhibin model) [ 17].
Such dual effect of the TGF-β signaling might be influenced by the varying TIF1γ/Smad4 ratios resulting in the modulation of the transcriptional signal induced by TGFβ as suggested by Andrieux et al. [ 32].
In concordance with HMGB1 acetylation status, LPS-primed release of HMGB1 was also influenced by the modulation of SIRT1 expression and activity.
On the basis of in vitro [ 135, 136] and in vivo [ 137] studies, it has become clear that A2A, through complex mechanisms which are still poorly understood [ 138– 141], plays a critical role in the modulation of inflammatory reactions, influencing functional outcome in a broad spectrum of pathologies including neurodegeneration [ 142, 143].
Similarly, the identity of viral proteins involved in the modulation of host cell pathways influencing CoV pathogenesis should be analyzed.
