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Although much progress has been made in identifying genetic factors that influence susceptibility to autoimmune diseases, progress is lacking in identifying those factors that influence disease progression or complications.
This model strongly suggests that changes in the expression or subcellular localization of α-catenin may influence disease progression.
To test the hypothesis that HTT protein levels decline with age, which together with HTT mutation could influence disease progression.
Hepatitis B virus (HBV) genotypes influence disease progression and treatment outcome.
Thus, chemotherapy drugs originally selected for their direct cytotoxicity to tumor cells may also influence disease progression by inducing changes in the tumor microenvironment.
Polymorphisms in genes encoding immunoregulatory proteins, proinflammatory cytokines, and fibrogenic factors may influence disease progression in patients with alcohol-induced liver disease, primary biliary cirrhosis, or chronic hepatitis C.
These findings provide tentative evidence that rs715212 and/or linked variants may influence disease progression in early-onset patients by altering the methylation or functionality of ADAMTSL1 and/or the expression of AREG either directly or via regulation of other members of the ADAMTS gene family.
Serial analysis of individual CTCs isolated from blood samples taken over the course of treatment may be used to identify new mutations that emerge in response to therapy which influence disease progression or therapeutic resistance [88], enabling oncologists to alter treatment accordingly.
Both drug therapy and neurorehabilitation have shown to ease the burden of some symptoms, even though neither influence disease progression.
Other, as yet unknown susceptibilities may influence disease progression.
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Characterization of the structural and functional progression of ocular von Hippel-Lindau (VHL) disease and analysis of patient factors influencing disease progression.
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