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Arcalyst works by blocking the action of an inflammatory protein called interleukin-1.
Sherry, B. et al. Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 β.
"Because you find an inflammatory protein in a certain disorder, it doesn't mean that it is causing that disorder".
Wolpe, S.D. et al. Identification and characterization of macrophage inflammatory protein 2.
Humira, which Abbott developed with Cambridge Antibody Technology of Britain, works the same way as the other two drugs, by blocking an inflammatory protein called TNF-alpha.
Greaves, D. R.et al. CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3α and is highly expressed in human dendritic cells.
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Davatelis, G. et al. Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen.
The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity.
The more severe pathology induced by LPS + BAY was associated with marked increases in lung and plasma levels of macrophage inflammatory protein-2 (MIP-2).
We identified two IgG4-RD patient-derived clonal plasmablast antibodies that bound to IL-1 receptor antagonist (IL-1RA) and macrophage inflammatory protein-3 (MIP-3/CCL23).
Gao, J.L. & Murphy, P.M. Cloning and differential tissue-specific expression of three mouse β chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 α receptor.
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