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There was no obvious association with inflammation, ulceration or infiltrative edge and location of HIF-2 α positive staining.
Infiltrative edge was only detected in 14 cases (19.2%) in our series, which was similar to that reported by Tsuda et al. [ 3].
In our study serial stereotactic biopsy, which delivers multiple samples from a trajectory calculated to traverse the most aggressive parts of the tumour based on MR imaging, and intraoperative diagnosis for both biopsies and resected cases ensured that solid tumour tissue rather than infiltrative edge was available for diagnosis.
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The remaining 14 cases (19.2%) showed poorly-defined boundaries with infiltrative edges.
Most tumors had well-defined boundaries, but 14 (19.2%) with infiltrative edges.
More recently, the concept of a 'spiculated' margin (Fig. 3) has been introduced to describe the finding of a distinctly infiltrative nodule edge (as separate from the broader 'poorly defined' category) with 92 % specificity and 81%% positive predictive value in a comprehensive review of B mode ultrasound findings [9].
Finally, the tumour border configuration was defined as "pushing" when tumours were smooth and rounded and they appeared to push into adjacent tissues, while it was defined as "infiltrative" when an irregular leading edge of cells infiltrated normal tissues with small groups of separated cells (96% of concordance; kappa value = 0.89).
Basal cell carcinoma, infiltrative micronodular type with perineural infiltration.
In those cases in which notable PLK1 expression was present and in which infiltrative tumour margins could be seen, PLK1 expression was accentuated on the leading edge of tumour invasion.
Histologic features, such as infiltrative lesions, reactive B-cell follicles, and lymphoepithelial lesions, overlapped between reactive infiltrates and conjunctival MZL.
"Now, that looks like a cancer, that little smudgy, irregular, infiltrative thing," Dershaw said.
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CEO of Professional Science Editing for Scientists @ prosciediting.com