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Table 3 lists the topmost five upstream mammalian receptors inferred to activate these I/U-DEGs.
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The only other environmental contaminant inferred to be able to maximally activate a ligated receptor is TCDD (Table 4).
Reported in the Oct4 cluster, Rela, which binds to M00052_NFKB sites, was inferred to co-bind with STAT3 and Smad1 for activating genes at DF stage.
Thus, because AMS049 is a lactone (cyclic ester), it is possible to infer its capacity to activate Nur77, triggering apoptosis.
Based on the results of the present study, we infer that CAP37, an established inflammatory mediator previously shown to activate microglial cells, may mediate the chronic neuroinflammation associated with AD from within the brain parenchyma.
Although not explicitly confirmed in this study, the authors inferred that the mutants either affected the catalytic activity or expression levels of CPR, thereby reducing its ability to activate paraquat.
By acute Csk inhibition, we were able to activate significantly more Lck molecules and based on the plateau level, we inferred an estimate of the basally active fraction.
The biofeedback inferred about the driver's ongoing physiological state using this neural network based inference engine would provide crucial information to on-board safety embedded systems to activate accordingly.
(To activate: scroll, select, click).
Time to activate the PODs.
I reached up to activate the roof.
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