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Both feedback gains and system stability are inferred simultaneously.
The modules, regulators and paths are inferred simultaneously, resulting in the most probable physical model of gene regulation that underlies the observed data.
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Starting from time-course gene expression data, ARTIVA performs a gene-by-gene analysis and infers simultaneously (i) the topology of the regulatory network, and (ii) how it changes over time.
This model is based on a combination of DBN and RJMCMC sampling, where RJMCMC is used for approximating the posterior distribution and DBN is used for inferring simultaneously the change points and resulting network structures.
For that we use a combination of efficient and robust methods: dynamical Bayesian networks (DBN) to model directed regulatory interactions between genes and Reversible Jump MCMC for inferring simultaneously the times when the network changes and the resulting network topologies.
The ARTIVA approach allows us to reverse engineer the temporally varying structure of transcriptional networks by inferring simultaneously the times at which regulatory inputs of genes change and the nature of these incoming inputs.
Finally, as mating systems may be different between the two species under study and selfing rates could influence deme structure in mixed-mating species, we used INSTRUCT to infer simultaneously the selfing rates of R. mangle and its genetic structure at two levels: (2) Between two estuaries along same coastline and (3) Within estuaries.
A third class of approaches can be labeled "single-stage" methods, in which species trees are inferred by simultaneously modeling the evolution of sequences among all sampled loci to output a species tree estimate [ 17- 20].
The epidemiological studies that have observed positive associations between ApoC3 and components of the metabolic syndrome (10, 12) have failed to take into account the fact that the role of ApoC3 cannot be inferred without simultaneously adjusting for serum triglycerides.
Another fault on the PA OK boundary was simultaneously inferred.
The value of (m 1 + m 2) can be simultaneously inferred from the slope of fitting curves (Eq. 11) in Fig. 3c.
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