For example, if Chemical A interacts with Gene B (via a curated chemical-gene interaction), and independently Gene B is associated with Disease C (via a curated gene-disease molecular mechanism or biomarker relationship), then Chemical A is said to have an inferred relationship with Disease C (inferred via Gene B).
Five expansin-like sequences of the social amoeba, Dictyostelium discoideum, were selected as outgroup based on their inferred relationship with land plant expansins [ 16, 86].
Therefore, arsenic has inferred relationships with 516 diseases in CTD.
Many techniques perform dimensionality reduction or other "compression" to show views of data in either two or three dimensions, leaving the data analyst to infer relationships with remaining independent and dependent variables.
A negative binomial regression model was used to examine the associations with testing rate, and to infer relationships with neighbourhood level sociodeomgraphic variables.
In addition, hip structural properties and risk of falling during follow-up were assessed with different methods than at baseline, so we were less able to infer relationships with incident fractures that occurred many years after the baseline visit.
Four conspecific haplotypes from Korea (KR) and Japan (JP-1, 2, 3) [GenBank: AF205087, AY315755~ AY315757] were also included in the phylogenetic analyses to help infer relationships with Chinese haplotypes.
These external data are similarly integrated with CTD core data to yield additional novel, inferred relationships.
Because of the nature of Affymetrix annotation, our methodology is restricted to inferring relationships for genes associated with a Blattner ID, constraining our network to 24 Hfq-dependent sRNAs.
These techniques capitalize on bioactivity data to infer relationships between the compounds, encoded with numerical descriptors, and their targets, which can be represented as labels in a classification model or explicitly encoded by e.g. protein or amino acid descriptors [4].
It is impossible to use traditional phylogenetic reconstruction methods to infer relationships between Alu elements, as, with their very high copy number, many elements in a young Alu subfamily share a consensus sequence, therefore the relationships between these elements could not be resolved.
