Exact(7)
In addition, we inferred positive population growth for most populations and detected evidence of historical gene flow between populations that are now physically isolated.
Goda et al. [ 36] also inferred positive selection at ABS sites, but not at non-ABS sites.
Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively.
We also computed the true positive rate (TPR), defined as the proportion of the inferred positive relationships that are documented in Yeastract.
We inferred positive selection in the human lineage applying the polarized MK test (McDonald and Kreitman 1991) on genomic data from three different populations (YRI, CEU, and CHB) along with three reference genomes (human, chimpanzee, and gorilla).
Still, the origin of the inferred positive selection remains elusive, given the small predicted impact of the observed amino acid substitutions in protein function.
Similar(53)
For example, when inferring positive selection, it would be more accurate to base inferences on all possible/plausible alignments, models, model parameters, and trees than to base them on one or a subset of possible alignments.
The reliance of three M2 vs M3, M7 vs M8 and M8 vs M8a nested LRTs to infer positive selection also provides some protection against false positives identified as a result of potential recombination events [55].
Radical replacements are assumed to be more likely than conservative replacements to alter the structure and function of a protein based on compositional factors and may not be used to infer positive selection [28].
A third method was used for inferring positive selection by utilizing nine-spined stickleback SNPs.
That is, we could not infer positive selection acting on any of the three mtDNA-encoded COX subunits.
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