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Our current understanding of miRNA function is inferred largely from studies of the effects of miRNAs on steady-state mRNA levels and from seed match conservation and context in putative targets.
Finally, the canonical sequence of HSE 5 bp subunits has been inferred largely from a single species, D. melanogaster, with inherent ascertainment bias.
Therefore, the gains inferred largely outnumbered the losses inferred when S. paradoxus was used as an outgroup for the pairwise comparisons of S. cerevisiae strains (supplementary table S2 b, Supplementary Material online).
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In addition, within Madagascar, the two major clades inferred correspond largely to the aglyphous and opisthoglyphous genera, suggesting that feeding specializations associated with tooth venom delivery may have played a major role in the early diversification of this radiation.
Although many statutes now require an overt act as proof of an agreement to commit a felony, conspiracy is still largely inferred from circumstantial evidence.
Beaver have well known effects on hydromorphology through dam construction, but their scope to restore wetland biodiversity in areas degraded by agriculture is largely inferred.
The existence of a terrestrial Precambrian (more than 542 Myr ago) biota has been largely inferred from indirect chemical and geological evidence associated with palaeosols1,2, the weathering of clay minerals3 and microbially induced sedimentary structures in siliciclastic sediments4.
We conclude that the major factor controlling enzyme susceptibility is granule architecture, with shorter length scales not playing a major role as inferred from the largely invariant nature of numerous structural measures during the digestion process (XRD, NMR, SAXS, DSC, FACE).
The mineralogy of asteroids is largely inferred by matching their visible near-IR reflectance spectra with those obtained from meteorites.
Although the ranges of co-eruptive, pre-eruptive (here defined as occurring in the year before an eruption) and inter-eruptive inferred maximum depths largely overlap (Figure 2D), the mean value for deformation sources involved in co-eruptive deformation is ~ 2 km shallower than that for those not associated with eruption.
Genes in the lactation pathway have been well-described but are largely inferred from mouse studies [ 10- 13].
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