Exact(5)
The method proposed in [ 10] inferred a total of nine edges, of which only one is correctly inferred edge.
For each inferred edge, a non-parametric significance test for mutual information is performed.
This was iterated 1000 times and the number of every inferred edge was counted.
This benchmark is meant to test only the accuracy of the inferred edge direction, which is the novel part of IDEM.
The newly inferred edge cJUN →ErbB-1 in HCC1954 also indicated raised activity of ErbB-1.
Similar(55)
Besides the benefit of improving the efficiency of inference, the precision of inferred edges may increase as well, since the clusters might cut off incorrectly inferred edges of traditional approaches.
The ExTILAR inferred TFN consists of 91 inferred edges, four auto-regulatory edges, 27 input-to-gene edges (Table 3) and 60 gene-to-TF edges.
Through experiments on real datasets (which will be introduced later), we found that although the extracted clusters from the clustering phases of I-CENI and C-CENI can help us shorten the running time of the inference phase, the F-measure of inferred edges on some datasets may be much worse than the results of state-of-the-art methods.
The true network and the networks reverse engineered using the proposed algorithm and the network MDL are shown in Figure 2. Of the 30 edges inferred by our approach nine are correctly inferred edges.
Through substantial experiments on two real datasets, we show that P-CENI can run in a similar time as I-CENI and C-CENI, while still preserves or even improves the effectiveness of state-of-the-art network inference algorithms in terms of the F-measure of inferred edges.
NetInf iteratively adds the "most likely" existed edge to the set of inferred edges to uncover the unknown information network.
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