The UGDP results have been debated concerning the study's nonrandomized design and low statistical power to test the hypothesis of inferior cardiovascular safety for sulfonylureas versus placebo.
These might be true observations of inferior efficacy and/or safety.
The complex design obtained from the AR method is technically and economically superior to a single adiabatic reactor but it is inferior from a safety perspective as a result of its complex interconnections and its high preheat temperature.
Other medications used similarly to control asthma symptoms, such as bronchodilators and theophyllines, have inferior efficacy and/or safety profiles compared with inhaled corticosteroids [ 2, 4, 5].
We performed a phase III clinical study of a JE-VC prepared with the Beijing-1 strain, KD-287, with the aim of determining whether its immunogenicity is not inferior and its safety is comparable to those of the currently used JE-MB prepared with the Nakayama strain, JEV-GCC, in Korean children.
On the basis of our analyses, suffice it to say that daptomycin does not have an inferior efficacy and has safety equivalent to comparator drugs, especially when compared with vancomycin which has been considered as the standard therapy for cSSTIs.
As the PCT intervention arm should be non-inferior, in terms of safety (mortality), in comparison to the standard treatment, the non-inferiority margin for PCT guided antibiotic management regarding 28-day-mortality is set on 8%.
Some of the top women's players even filed a gender discrimination lawsuit against Fifa and the Canadian Soccer Association over the decision to hold the Women's World Cup on artificial turf – an "inferior surface" that posed "unique safety risks", and one on which the men would never be required to play.
Objective response rates with raltitrexed are similar to those with 5-FU plus LV (Cunningham, 1998) but recent trials have demonstrated inferior efficacy (TTP/survival) or raised safety concerns.
Cheaper models may also be of inferior quality and could cause passenger safety and experience have to suffer.
