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These might be true observations of inferior efficacy and/or safety.
The relative inferior efficacy of the nanoparticles compared with the standard formulation of paclitaxel could be explained by a difference in the oral uptake of the drug.
It is difficult to determine if these patients had higher mortality rates because of their initial presentation, or due to the inferior efficacy of the treatment itself.
In particular, triptans should be used in preference to ergotamine, which not only has inferior efficacy but also raises concern over toxicity, accumulation and overuse potential [6].
Paracetamol was not included in the analysis as it is considered to have inferior efficacy compared with NSAIDs [18] and, thus, rarely used for managing pain in Saudi OA patients.
Eiland et al. 2001 have successfully co-composted Miscanthus straw with pig slurry at low initial C/N ratio of 11 to 35.The authors found that low initial C/N ratios led to high degradation rate (40%to8080%) of both cellulose and hemicellulose indicating high microbial activities, whereas high initial C/N ratios yielded inferior efficacy, approximately 10%to20%0% degradation.
Similar(32)
In recent years, RCTs conducted in Asian and Africa countries observed inferior efficacies of two internationally available RV vaccines, namely RotaRix and RotaTeq.
In conclusion, pyronaridine-artesunate had non-inferior efficacy and faster parasite and fever clearance compared with chloroquine against P. vivax.
Therefore, the data support the conclusion of non-inferior efficacy.
The hypothesis of the study was that robenacoxib would have non-inferior efficacy and tolerability compared to meloxicam.
Therefore a combination of non-parametric and parametric tests was used, and using both approaches provides greater confidence that robenacoxib had non-inferior efficacy compared to meloxicam.
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