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This approach arranges the data based on similarity and does not require a pre-definition or inference of the number of classes.
To model clusters of clonal and subclonal point mutations, allowing inference of the number of subclones and the fraction of cells within each subclone, we used a 2-D Bayesian Dirichlet analysis as previously described for all patients with paired samples11,42.
In this work, we have shown how the basic admixture model can be extended to allow automatic inference of the number of populations.
The inference of the number of clusters in a dataset, a fundamental problem in Statistics, Data Analysis and Classification, is usually addressed via internal validation measures.
Evolutionary studies of oceanic island lineages share common goals such as the identification of continental sister taxa and the inference of the number, timing and directionality of colonization events among archipelagoes and islands [ 36].
Coalescent simulations by Huelsenbeck and Andolfatto (2007) using island models show that inference of the number of populations is accurate when migration rates are low and differentiation between populations is high.
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3 In addition to trial sequential analysis of the current meta-analysis data, our analysis provides an inference on the number of patients that would be required to be further randomized to provide stronger evidence.
For the cryptic caecilians, we and other labs have used comprehensive PCR surveys of the conserved homeodomains to make inferences on the number of Hox genes [ 20, 21].
However, it is important to emphasize that the methodology and study design do not enable us to make inferences on the number of veterinarians in each identified categories of motivation.
We also examined TRD across the genome and its impact on the genetic analyses and inferences on the number of genes involved in restoration.
As a result of this, the method generates inferences of the number of clones detected in the sample, their population frequencies across time and/or space, and subclone-specific posterior probabilities of copy-number profiles and somatic variant genotypes.
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