The theory is complex and I will not explore it further here, beyond emphasizing, once again, that the content of a thought is determined by the ways in which we can use it in inference and the planning of action.
This data set, publicly available at http://ecoliwiki.net/tools/chemgen/, is a valuable resource for both the microbiological and bioinformatic communities, as it provides high-confidence associations between hundreds of annotated and uncharacterized genes as well as inferences about the mode of action of several poorly understood drugs.
Although they do not support inferences regarding specific mechanisms of action, the results from a MSCM clearly suggest that more aggressive antihypertensive regimens are associated with a reduced rate of serious cardiovascular events in patients with hypertension and prevalent CAD.
Using factor analysis over phenotypic profiles, chemical similarity, and predicted protein binding, Feng and colleagues derived mechanism of action inferences from a high-content cellular screen (HCS, selections in Table 2) (60).
Other functionalists agree that we may advert to various norms of inference and action in attributing beliefs and desires to others, but deny that there is any in principle incompatibility between normative and empirical explanations.
In the context of action, acted inference finesses the problems with delayed control signals in classical formulations of motor control by replacing command signals with descending corticospinal predictions.
We also seek an approach that integrates inferences across different and diverse kinds of data that can tie together inference based on epidemiology, animal testing, and mode-of-action and pharmacokinetic data.
It may be thought that active inference implies a stimulus-driven account of action.
In predictive coding accounts of action selection (active inference), dopamine is thought to encode the precision (gain) of prediction errors that induce and maintain a particular response set (Friston et al. 2012; Galea et al. 2012).
It seems, however, that only an individual agent's own intentional states can commit them to a particular course of action, or to inferences.
"Harmonization" should mean stressing compatibility of inferences about underlying pharmacokinetics and modes of action and using the insights developed in dissecting the underlying biology of different endpoints to inform our understanding across endpoints.
