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Largely due to the elusive nature of lincRNA functional mechanism, it's still hardly practical to infer functions of lincRNAs from their nucleotide sequences solely [ 24].
We used the structural motifs to infer functions of 13 novel PKs/NRPs clusters produced by Pseudomonas spp. and Burkholderia spp. and found a putative virulence factor.
Hence, it may be possible to infer functions for a protein based on its interaction partners.
Currently, a great diversity of protein similarity measures are used to infer functions.
Established methods use sequence or structure similarity to infer functions but those types of data do not suffice to determine the biological context in which proteins act.
We selected this cDNA cluster for further investigation in an attempt to infer functions for uncharacterized genes based on co-expression with known genes and sequence analysis.
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Orthologs are, by definition, more likely to share functional similarity [ 38] and orthology can be used to reliably infer function to their co-orthologs.
However, efforts to infer function from such activity measurements have been limited.
It has been suggested that gesture engrams, conceptual knowledge and/or the ability to infer function from structure can support object use.
Using high throughput RNA sequencing and a physical interaction pulldown assay, we were able to infer function of miR-29a in the different liver cell populations in vitro in the presence or absence of synthetic injury.
However, these methods often meet with limited success due to our inability to completely infer function from structure [30].
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