Exact(43)
Orthologs are, by definition, more likely to share functional similarity [ 38] and orthology can be used to reliably infer function to their co-orthologs.
Therefore, until we have a large-scale sampling of non-coding functional elements in the human genome that we can use to infer function of other non-coding elements, a practical solution might consist of utilizing the classical GO analysis approach, applying the proposed correction, and analyzing differences and commonalities in the results.
However, efforts to infer function from such activity measurements have been limited.
It has been suggested that gesture engrams, conceptual knowledge and/or the ability to infer function from structure can support object use.
Using high throughput RNA sequencing and a physical interaction pulldown assay, we were able to infer function of miR-29a in the different liver cell populations in vitro in the presence or absence of synthetic injury.
However, these methods often meet with limited success due to our inability to completely infer function from structure [30].
Similar(17)
Largely due to the elusive nature of lincRNA functional mechanism, it's still hardly practical to infer functions of lincRNAs from their nucleotide sequences solely [ 24].
We used the structural motifs to infer functions of 13 novel PKs/NRPs clusters produced by Pseudomonas spp. and Burkholderia spp. and found a putative virulence factor.
Fold similarities have been shown to associate with function [13], [14], and have also been used to infer function-specific sequence patterns [15].
Currently, a great diversity of protein similarity measures are used to infer functions.
Hence, it may be possible to infer functions for a protein based on its interaction partners.
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