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In situations without minimally disturbed sites and historical data, empirical models derived from associations between biological indicators and human-disturbance gradients can be extrapolated to infer conditions in the absence of human disturbance (Stoddard and others 2006).
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To infer condition-mediated ASE changes of genes, we pairwise-compared their log2FCs under non- and water-stress conditions (Additional file 1: Table S1 and Additional file 2: Table S2).
However, it can also infer condition-specific modulation of post-translational TF activity when used in conjunction with gene sets consisting of putative TF targets.
In this paper, we demonstrate how prior information about regulatory network connectivity can be exploited to infer condition-specific TF activity as a hidden variable from the genomewide mRNA expression pattern in the yeast Saccharomyces cerevisiae.
BitSeq probabilistically infers condition mean expression levels using all replicates.
We presented PIMiM, a new method for inferring condition-specific regulation of miRNAs and for identifying their targets.
Using metabolic models as scaffolds for the analysis of high throughput data such as transcriptomics, proteomics and metabolomics suggests the possibility of inferring condition-dependent changes in the metabolic activity of an organism.
We investigated the palynology of sediment cores from Site M0027 (IODP Exp. 313), 45 km off the present-day coast of New Jersey to infer palaeoenvironmental conditions during the second half of the Mid Miocene Climatic Optimum and the transition to global cooler conditions.
Using drug-disease knowledge bases to infer pathological conditions from medications is a feasible and useful technique to complete the coding of pathological conditions.
Pollen from hyena coprolites are useful to describe palaeovegetation and to infer palaeoclimatic conditions.
However, caution needs to be extended when using data from outcrop samples to infer underground conditions.
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