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Sexually transmitted infections (STIs) increase HIV infectivity through local inflammatory processes.
We cannot exclude the contribution of other endogenous viruses to putative infectivity through pseudotyping or recombination.
Previously, it was demonstrated that increased Gag-Pol levels severely impair virion infectivity through disruption of RNA genome dimerization [62].
We then asked whether the suppression of HIV-1 infectivity through Mov10 overexpression was due to reduced HIV-1 particle production.
The position of the surface-exposed epitope is consistent with a direct role of AVFluIgG01 in neutralizing virus infectivity through binding the epitope on the HA spike and block attachment of virus to the receptor.
The presence of higher levels of processing intermediates in virus produced in these cells may help explain the reduced infectivity, as studies in both MLV [65] and HIV [7] demonstrate that partially cleaved Gag products act transdominantly to reduce virion infectivity through reduced reverse transcription of viral RNA, despite the presence of functional Reverse Transcription polymerase [7].
Similar(46)
One proposes that host and parasite populations cycle through different resistance and infectivity genotypes through time, but that each genotype is a specialist only capable of resisting or infecting one genotype of the other species.
The continual supply of 'good' resistance and infectivity traits through migration may, for example, increase the magnitude of escalation before this happens.
The sheep were housed in Biocontainment Level 3 facilities to constrain any BSE infectivity spreading through the faeces and to avoid any risk of cross-contamination with scrapie.
After oral transmission, infectivity passes through the gut to secondary immune tissues and then to the brain (Aguzzi and Heikenwalder 2005).
When the infected individual is in the acute or AIDS stages, the infectivity is increased through multiplying by δ a or δ b, respectively.
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