Sentence examples for infectivity control from inspiring English sources

The challenge model traditionally used to assess efficacy of pre-erythrocytic vaccine candidates is robust: at WRAIR, a 100% infection rate has been obtained in the last 100 infectivity control volunteers fed upon by 5 Anopheline mosquitoes which were each highly infected with P. falciparum sporozoites.

To assess the efficacy of the vaccines the 24 vaccinated subjects and 6 unvaccinated infectivity control subjects underwent experimental challenge with Plasmodium falciparum, fourteen days after the final vaccination.

Among the three groups (two full dose vaccine groups and infectivity control group), there was a strong, statistically significant difference in longitudinal measurement of peripheral parasitemia on Days 7 9, the days in which peripheral parasitemia was detected and measured by qPCR and no treatment with chloroquine had yet been initiated (p = 0.0002, repeated measures ANOVA, data not shown).

One infectivity control died during the second year of follow-up for reasons unrelated to participation in the clinical trial.

One of the 15 non-vaccinated controls was enrolled as an extra volunteer to replace any infectivity control drop-outs, one was enrolled as a source of malaria-naïve peripheral blood mononuclear cells (PBMC) for cohort 4 (immunological control) and 13 were enrolled as infectivity controls or as both infectivity controls and immunological controls.

The Group A sham-vaccinated animals served as protocol-specified infectivity controls in order to confirm consistent infection by the FVO parasite inoculum and its appropriate adaptation to growth in Aotus.

Of these, 47 were eligible, 35 were enrolled as vaccinees, and 6 were enrolled as infectivity controls.

Of 27 vaccinees eligible for malaria challenge, 16 elected to undergo malaria challenge along with 6 unimmunized infectivity controls.

Six healthy, malaria-naive adults aged 18 to 50 years were also enrolled as non-immunized infectivity controls.

The recruitment period began September 11, 2006, was completed for vaccinees at the end of October 2006, and a second brief recruitment period for infectivity controls occurred during the month of January 2007.

A sensitive, quantitative PCR analysis also did not reveal any statistically significant delay in the time to parasitemia in vaccinees versus infectivity controls.