How the application of combinatorial techniques can impact anti-infectives research will be reviewed using illustrative examples.
The development of new antibacterial agents to combat worsening antibiotic resistance is still a priority area in anti-infectives research, but in the post-genomic era it has been more difficult than expected to identify new lead compounds from high-throughput screening, and very challenging to obtain antibacterial activity for lead compounds.
2 It has long been speculated that in-cell NMR could make useful contributions to the drug discovery process, 3 particularly in the area of anti-infective research on serious bacterial pathogens.
These AMPs have been found to be expressed in some inflammatory, infective and malignant diseases, so further research is needed to elucidate the biological function of these AMPs in KS.
Effective surveillance systems or research programs devoted to anti-infective resistance in infectious diseases such as tuberculosis, malaria, or HIV have been implemented over the past few years with the active support of various stakeholders (donors agencies, governments, research institutes).
Dr. Michael W. Dunne, director of clinical research for Pfizer's anti-infective drugs, said the company had conducted studies comparing Zithromax to all drugs recommended by the C.D.C. panel and found that Zithromax was just as effective.
This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB.
Because of frequent price fluctuations, product variations, policy changes, and specific prescribing patterns, anti-infective agents were not suitable for this research.
This has been exemplified in a review on anti-infective high-throughput screens by the GlaxoSmithKline research laboratories (Collegeville, Pennsylvania, USA), which indicated that the success rate of the path that linearly follows essential genes through high-throughput screens in the quest for novel anti-infectives has been abysmal.
Limited research has been conducted on healthcare-associated infective endocarditis (HAIE), although it is of increasing importance.
An example of such an agency is the National Institute for Medical Research, which has been carrying out research in Nigeria for more than thirty years on parasitic, infective and non-infective diseases.
