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P139 Lymphopenia after severe infectious shock in children: association with severity and risk for nosocomial infection.
The study was registered: Pediatric Immune Response to Infectious Shock (PedIRIS).
Conclusion Initial lymphopenia in children with infectious shock was linked to initial severity of shock, and the most severe patients were more at risk of day 3 lymphopenia.
Introduction To describe the time course of lymphocytes in children with severe infectious shock and to search for an association between persistent lymphopenia, initial severity and risk for nosocomial infection.
Patients and methods This monocentric retrospective study enrolled all children aged less than 18, admitted to PICU for severe infectious shock between January 2011 and September 2014, excluding immunosuppressed and died within the first day.
Infectious shock incidence increased significantly from 1993 through 2006 (R = 0.708, p<0.001 by linear regression).
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Immunomodulation therapy perspectives need better knowledge of immunosuppression induced by different severe infectious shocks.
Among these, 47 were excluded (toxic shock syndrome, non-infectious shock, known immunosuppression, or chronic inflammatory disease).
Twenty-two crillchildrenl children (age 0.89 ± 0.04 years) with different levels of inflammation were studied on day 3 post-admission; viral bronchiolitis (group 1, n = 9), infectious disease without shock (group 2, n = 6) and septic shock (group 3, n = 7).
The shock, infectious syndrome, purpura, neurological and respiratory disorders dominated the clinical background at admission.
There is a slight increase (less than 5 times the ULN) in pancreatitis, shock, infectious mononucleosis and heart attack.
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