Browne, S. K. & Holland, S. M. Anticytokine autoantibodies in infectious diseases: pathogenesis and mechanisms.
The impact of these findings on the understanding of infectious disease pathogenesis and on the design of future preventive and therapeutic strategies should be considerable.
Since the 18th century a wealth of knowledge regarding infectious disease pathogenesis, prevention, and treatment has been accumulated from findings of infection challenges in human beings.
Yet, we believe that recent developments in a number of areas such as infectious disease pathogenesis research, translational medicine, mAb engineering, mAb manufacturing and rapid bedside diagnostics are converging to make the medium-term future permissive for antibacterial mAb development.
Not only does this investigation provide experimental evidence for the validity of the candidate 89K PAI, but it adds novel insights into the infectious disease pathogenesis of SS2.
At present, molecular studies on the immune response to pathogens in fish models are mainly focused on infectious disease pathogenesis.
This approach can be used to investigate their individual contributions to the immune response and infectious disease pathogenesis (Gray et al., 2011; Prajsnar et al., 2012).
As such, genomic research is improving our understanding of infectious disease pathogenesis and immune response and may help guide future vaccine development and treatment strategies [ 11– 11].
Stegenga et al. dissected out the separate roles of insulin and glucose in infectious disease pathogenesis by studying healthy volunteers in whom insulin and glucose levels were maintained at preset levels for 6 8 h using tightly controlled infusions of insulin, glucose, somatostatin and glucagon, and intravenous E. coli LPS given to simulate sepsis [ 124].
In recent years, the zebrafish (Danio rerio) larval model has become an accepted model system for the study of infectious disease pathogenesis (Neely et al., 2002; Prouty et al., 2003; van der Sar et al., 2004; Sullivan and Kim, 2008; Li and Hu, 2012; Tobin et al., 2012) that offers several advantages over rodent animal hosts.
